The current study focused on the production of sweet lozenges with the goal of enhancing bioavailability. To examine whether there were any interactions between the medications and the different formulation components, FT-IR was used and no interactions were found. Resveratrol lozenges were made by combining different polymers, such as HPMC K4M and Chitin, in various ratios. The prepared lozenges had an average weight of 2.16±0.006 to 3.08±0.004 gram, a percent friability of 1.86±0.008 to 2.14±0.003, a hardness of 10.15±0.004 to 12.27±0.003 kg/cm2, a disintegration time of 23.35±0.007 to 24.25±0.0012 minutes, a percent drug content of 96.5±0.006 to 99.4±0.005 and a percent moisture content in the range of 0.5±0.015 to 0.8±0.026 of based on all of the assessment factors, ZL2 was chosen as the optimal formulation. The in-vitro drug release was carried out in phosphate buffer with a pH of 6.8 and it was discovered that the drug release is dependent on the polymer concentration. The improved formulation ZL2's drug release kinetics were most closely related to zero order kinetics and the Korsmeyer-peppas drug release mechanism. The stability assessment of the improved formulation reveals no major changes in the product. According to the aforementioned findings, the influence of polymers such as HPMC K4M exhibits superior results in heat congealing method for the manufacturing of lozenges.
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